A cancer diagnosis can be shattering to an individual and his or her family and friends. The emotional earthquake can make everyone’s mind turn to mush. What does it mean? What do you do first? What are the right questions to ask? This article is intended to empower people confronted by a cancer diagnosis with an overview of the first steps in the treatment process to find their treatment options, updated to take into account the new possibilities offered by technologies for personalization of cancer treatment. In addition to establishing a support team and learning about your disease, treatment, and immediate steps, it’s important to get tests of the genetic profile of your disease and see if the latest targeted and immunotherapy treatments are options you should consider.